ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Growth factor applications and clinical translation: advances and challenges.Annals of medicine · 2026Review
- FGF8 alleviates LPS-induced acute lung injuryAnnals of medicine · 2026Article
- CiCXCL14 Exhibits Broad-Spectrum Bactericidal Activity and Protects Grass Carp AgainstAnimals : an open access journal from MDPI · 2026Article
- Potential of Antimicrobial Peptide Synergies for Combating Infectious Diseases in Aquaculture: A Review.Animals : an open access journal from MDPI · 2026Review
- Bioengineered probiotics derived bacterial extracellular vesicle as bioactive nanocarrier for the local VEGF expression to accelerate wound healing.Journal of nanobiotechnology · 2026Article
- Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Repairing and preventing infections of skin wounds are crucial for the body health. Fibroblast growth factors (FGFs) have functions of repairing skin wounds, while antimicrobial peptides/proteins (AMPs) can prevent the infections of skin. Therefore, if FGFs can act like AMPs, they will have better application potential in promoting skin wound healing. Here, it is found that grass carp fibroblast growth factor 8a (gcFGF8a) has broad-spectrum and potent antibacterial activity through disrupting the cell membrane, indicating that FGF8 is an uncovered AMP. Further study revealed that gcFGF8a can accelerate skin wound healing through dual functions: inhibiting bacterial and activating of glycolysis. Mechanistically, gcFGF8a/FGFR4 signaling induces epithelial cell glycolytic programs for barrier remodeling through the mTORC1/HIF1α pathway. Interestingly, it is found that mouse FGF8b (mFGF8b), the homolog of gcFGF8a, also has antibacterial and skin wound repair activities, indicating that FGF8 is a functionally conserved molecule in vertebrates. To the knowledge, FGF8 is the only member of the FGF family with both antibacterial and wound repair functions at present, greatly enriching the understanding of this pivotal molecule. Furthermore, these findings highlighted the potential application of FGF8 as a skin wound repair drug.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.