ArticlePsychoradiology2025
Activity of the default mode network mediates the effect of peripheral plasma glial cell line-derived neurotrophic factor levels on rumination in major depressive disorder patients.
Article in Psychoradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Graph theory reveals functional connectome disruptions in adolescent major depressive disorder with childhood trauma.Communications medicine · 2026Article
- The association between spatiotemporal coupling of default mode network and behaviors is specifically modulated by peripheral inflammation in major depressive disorder.BMC psychiatry · 2026Article
- Peer bullying victimisation and depressive symptoms as serial mediators between attention-deficit/hyperactivity disorder symptoms and internet gaming disorder among Chinese adolescents: A three-wave longitudinal study.General psychiatry · 2026Article
- Gamma-band cortical functional network abnormalities in late-life depression with suicidal ideation: insights from EEG graph theory and machine learning.Journal of psychiatry & neuroscience : JPN · 2026Article
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14 authors.
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Abstract
Background: Rumination is a pivotal psychopathological process in major depressive disorder (MDD). The neurotrophic hypothesis suggests that glial cell line-derived neurotrophic factor (GDNF) might play a role in brain dysfunction and clinical symptoms of MDD. However, the relationship remains unclear. Methods: Thirty-three individuals with MDD and 33 healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) while performing a rumination state task designed to induce sustained, active rumination. The Ruminative Response Scale (RRS) was administered to assess individual rumination tendency. Brain activity within the default mode network (DMN) subsystems during rumination was characterized using both fractional amplitude of low-frequency fluctuations (fALFF) and functional connectivity (FC) analyses. Serum levels of GDNF and inflammatory markers [interleukin (IL)-6, IL-8, and C-reactive protein] were quantified in all participants. We then examined the relationships between regional brain activity (fALFF values), GDNF levels, and rumination severity (RRS scores) in the MDD group. Results: Compared to HCs, MDD patients exhibited significantly reduced serum levels of both GDNF ( Conclusions: In MDD patients, GDNF levels were associated with neural activity within the DMPFC subsystem of the DMN, which statistically mediated the link to rumination severity.
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