Evidence map›Paper›PMID 40585984›Full record

ArticleTheranostics2025

Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers.

Cao Dai Phung, Trinh T T Tran, Brendon Zhi Jie Yeo, Rebecca Carissa Prajogo, Evelyn Saudjana, Eric Yew Meng Yeo, Chang Gao, Phuong H D Nguyen, Migara Kavishka Jayasinghe, Xuan T T Dang and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Targeted therapeutic strategies forTranslational lung cancer research · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Cao Dai PhungDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Trinh T T TranDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Brendon Zhi Jie YeoDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Rebecca Carissa PrajogoDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Evelyn SaudjanaDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Eric Yew Meng YeoDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Chang GaoDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Phuong H D NguyenDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Migara Kavishka JayasingheDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Xuan T T DangDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Celest Phang LixuanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Trinh Mai NguyenLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Boya PengDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Anh Hong LeDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Tram T T NguyenDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Gloria Mei En ChanSynthetic Biology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Yuin-Han LohCell Fate Engineering and Therapeutics Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore, 138673, Singapore.
Boon Cher GohDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Wai Leong TamCancer Science Institute of Singapore, National University of Singapore, Singapore.
Glenn Kunnath BonneyCancer Science Institute of Singapore, National University of Singapore, Singapore.
Dahai LuoLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Minh T N LeDepartment of Pharmacology and Institute for Digital Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DEAD Box Protein 58Extracellular VesiclesProto-Oncogene Proteins p21(ras)Tumor MicroenvironmentAnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorColorectal NeoplasmsDendritic CellsHumansLung NeoplasmsMiceMutationPancreatic NeoplasmsReceptors, ImmunologicDEAD Box Protein 58KRAS protein, humanProto-Oncogene Proteins p21(ras)Receptors, ImmunologicRIGI protein, humanantisense oligonucleotidescancer therapyextracellular vesiclesKRAS mutationRIG-I agonist

Identifiers

PMID40585984
PMCPMC12203666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.