Evidence map›Paper›PMID 40585973›Full record

ArticleTheranostics2025

MiR-125a-5p in extracellular vesicles of neural stem cells acts as a crosstalk signal modulating neuroinflammatory microenvironment to alleviate cerebral ischemia-reperfusion injury.

Qingyue Liu, Heran Ma, Jing Liao, Zihan Zhu, Hongyuan Chen, Dong Sun, Longkun Wang, Lu Lu, Xiaowei Chen, Xinke Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Stem cell extracellular vesicles for neuropsychiatric disorders and translation.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qingyue LiuKey Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Heran MaQilu Cell Therapy Technology Co., Ltd, Jinan 250000, China.
Jing LiaoKey Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Zihan ZhuKey Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Hongyuan ChenDepartment of General Surgery, Shandong Provincial Hospital Affilated to Shandong First Medical University, Jinan 250021, China.
Dong SunDepartment of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan 250012, China.
Longkun WangDepartment of Pharmacy, Tianjin Anding Hospital, Tianjin 300000, China.
Lu LuDepartment of Pharmacy, Peking Union Medical College Hospital, Beijing 100010, China.
Xiaowei ChenBeijing Yinfeng Dingcheng Biological Engineering Technology Limited Liability Company, Beijing 100176, China.
Xinke ZhangKey Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Fengshan WangKey Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Brain IschemiaExtracellular VesiclesMicroRNAsNeural Stem CellsNeuroinflammatory DiseasesReperfusion InjuryAnimalsCellular MicroenvironmentHumansMaleMiceMicrogliaNeuronsSignal TransductionMicroRNAsMIRN125 microRNA, humancerebral ischemia-reperfusion injuryextracellular vesiclesIKBKGmiR-125a-5pneuroinflammation

Identifiers

PMID40585973
PMCPMC12203920

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.