Evidence map›Paper›PMID 40585971›Full record

ArticleTheranostics2025

Repurposing methimazole to promote coronary collateral circulation through MAPK1-mediated macrophage polarization via ferroptosis.

Ling-Ping Zhu, Wei He, Ke-Chuan Lin, Dan Wang, Lin-Lin Wang, Shuai Li, Mei-Lian Yao, Jing Chen, Mei-Fang Chen, Guo-Gang Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ling-Ping ZhuDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Wei HeDepartment of Emergency Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Ke-Chuan LinDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Dan WangDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Lin-Lin WangDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Shuai LiDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Mei-Lian YaoCoronary Circulation Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Jing ChenCoronary Circulation Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Mei-Fang ChenDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Guo-Gang ZhangDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Chuan-Chang LiDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Ling-Ping ZhuDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yong-Ping BaiDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Collateral CirculationCoronary CirculationFerroptosisMacrophagesMethimazoleAnimalsDisease Models, AnimalDrug RepositioningHumansMaleMiceMice, Inbred C57BLMyocardial InfarctionTHP-1 CellsMethimazolecoronary collateral circulationferroptosismacrophage polarizationMAPK signalingmethimazole

Identifiers

PMID40585971
PMCPMC12203669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.