ArticleJournal of surgical case reports2025
Neuroendocrine carcinomas of the larynx: a review of current literature and case analysis.
Article in Journal of surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroendocrine Carcinoma of the Submandibular Gland in an Older Adult: A Rare Case and Literature Review.The American journal of case reports · 2026Pooled it
- Collision of Hypopharyngeal Small-Cell Neuroendocrine Carcinoma and Laryngeal Squamous Cell Carcinoma at the Aryepiglottic Fold: Case Report and Review of Literature.Case reports in pathology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroendocrine carcinomas (NECs) of the larynx are rare malignancies with aggressive behavior, histopathological diversity, and poor prognosis. Their management remains challenging due to limited case reports and the lack of standardized treatment guidelines. We conducted a comprehensive literature review to summarize classification, diagnosis, and treatment approaches for laryngeal NECs. Additionally, we present a representative case of a 64-year-old male patient diagnosed with large cell NEC of the larynx, treated with surgical resection and adjuvant radiotherapy, with long-term follow-up. Laryngeal NECs require a multidisciplinary approach, and treatment should be tailored based on tumor grade, stage, and histopathological subtype. Advances in molecular profiling and targeted therapies may improve patient outcomes in the future. Due to their rarity, further prospective studies and international collaborations are needed to establish evidence-based treatment guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.