Evidence map›Paper›PMID 40585905›Full record

ArticleNeurobiology of stress2025

Adverse childhood experiences and internalizing symptoms: the moderating role of neural responses to threat.

Carola Dell'Acqua, Claudio Imperatori, Rita B Ardito, Benedetto Farina, Mauro Adenzato, Giuseppe Carbone, Aurelia Lo Presti, Daniela Palomba, Simone Messerotti Benvenuti

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In one paragraph

Article in Neurobiology of stress, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carola Dell'AcquaDepartment of General Psychology, University of Padua, Padua, Italy.
Claudio ImperatoriExperimental and Applied Psychology Laboratory, Department of Human Sciences, European University of Rome, Rome, Italy.
Rita B ArditoDepartment of Psychology, University of Turin, Turin, Italy.
Benedetto FarinaExperimental and Applied Psychology Laboratory, Department of Human Sciences, European University of Rome, Rome, Italy.
Mauro AdenzatoDepartment of Psychology, University of Turin, Turin, Italy.
Giuseppe CarboneDepartment of Psychology, University of Turin, Turin, Italy.
Aurelia Lo PrestiDepartment of Psychology, University of Turin, Turin, Italy.
Daniela PalombaDepartment of General Psychology, University of Padua, Padua, Italy.
Simone Messerotti BenvenutiDepartment of General Psychology, University of Padua, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse childhood experiences (ACEs) increase vulnerability to internalizing symptoms, namely symptoms characterized primarily by processes within the self, such as anxiety and depression, but the underlying processes are still unclear. One possible mechanism is that ACEs alter the neural correlates responsible for the preferential processing unpleasant stimuli, a key feature of anxiety. Another mechanism could be a stress-induced disruption in the processing of pleasant stimuli, which is mostly linked with depressive symptoms. In this study, we examined how ACEs and neural correlates of different emotional processing stages (affective engagement, anticipation, elaboration) interact in the association with internalizing symptoms in a sample of university students (

Indexed as

Adverse childhood experiencesAnxietyDepressionERPsP300/LPPSPN

Identifiers

PMID40585905
PMCPMC12206150

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.