ArticleJournal of the Endocrine Society2025
Recovery of Pituitary and Visual Function After Rathke's Cleft Cyst Decompression: An 80-case Institutional Experience.
Article in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Hyponatremia as the Initial Presentation of Rathke's Cleft Cyst-Related Hypopituitarism.Cureus · 2026Article
- Surgical outcomes and predictors of recurrence following endoscopic endonasal marsupialization of Rathke's cleft cysts.Acta neurochirurgica · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Rathke's cleft cyst can lead to visual and pituitary dysfunction. Surgical decompression may alleviate these issues, but the decision to operate remains controversial because of the risk of worsening function. Methods: A retrospective analysis was conducted on 80 patients who underwent endoscopic transnasal transsphenoidal surgery for Rathke's cleft cyst from April 2018 to April 2024. Clinical outcomes were assessed using magnetic resonance imaging, intraoperative findings, and histopathology to evaluate factors associated with recovery. Results: After a median follow-up of 13.5 months (interquartile range: 6-30.8 months), anterior pituitary function significantly improved in patients with cysts that did not compress the optic nerve and had minimal thinning of the ganglion cell layer-inner plexiform layer ( Conclusion: Decompression of Rathke's cleft cysts can improve anterior pituitary function in patients with smaller cysts and minimal optic nerve pressure. Visual function will likely improve in those with minimal optic nerve fiber layer thinning. Therefore, preoperative optical coherence tomography and visual field testing are mandatory to set expectations regarding potential improvement in vision and anterior pituitary function following surgery. Patients with preoperative adult GH deficiency and a history of surgery are at higher risk of developing postoperative arginine vasopressin deficiency.
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