ArticleJournal of the Endocrine Society2025
High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice.
Article in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Helminth infection induces RELMα-dependent adipose tissue transcriptional reprogramming and protection against diet-induced obesity.bioRxiv : the preprint server for biology · 2026Article
- Fibroblast growth factor 16: Molecular mechanisms, signalling crosstalk, and emerging roles in cardiac biology and metabolic regulation.Pharmacological research · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Context: Fibroblast growth factors (FGFs) play critical roles in metabolism, yet their tissue-specific expression in response to obesity and aging remains unclear. Objective: We investigated the mRNA expression profiles of FGFs along with their receptors, across major metabolic tissues-heart, liver, kidney, skeletal muscle, gonadal white adipose tissue, subcutaneous white adipose tissue, and brown adipose tissue. Methods: Young (7-week-old) and aged (12-month-old) male mice were fed either a high-fat diet (HFD) or a normal diet for 11 weeks. Real-time quantitative polymerase chain reaction was used to measure mRNA expression levels of FGFs and their receptors. Results: The FGF system exhibited widespread expression, with the heart showing the most pronounced response to HFD-induced stress, followed by the liver and kidney, while skeletal muscle exhibited minimal changes. Adipose tissues displayed distinct FGF expression patterns under HFD conditions, with FGF1 being the most responsive, followed by FGF9. Although aged mice exhibited significantly greater body and organ weights, FGF expression profiles showed minimal variation between young and aged mice in most organs except heart. Conclusion: These findings underscore the tissue-specific dynamics of the FGF system under metabolic stress, identifying FGF1 as a promising therapeutic target for addressing obesity- and aging-related metabolic dysfunction.
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Registered trials
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