Evidence map›Paper›PMID 40585857›Full record

ArticleTransboundary and emerging diseases2025

Emergence of Microvariants of African Swine Fever Virus Genotype II in the Asia-Pacific.

James O'Dwyer, Hung Vo Van, Nguyen Thanh Phuong, Patrick Mileto, Orlando Mercado, Felisiano da Conceição, Joanita Bendita da Costa Jong, Ilagi Puana, Matthew J Neave, David T Williams

Abstract read
In one paragraph

Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James O'DwyerAustralian Centre for Disease Preparedness, Commonwealth Scientific and Industrial Research Organisation, Geelong, Australia.ORCID https://orcid.org/0000-0003-3058-6295
Hung Vo VanDepartment of Animal Health, Regional Animal Health Office No. 6, Ho Chi Minh City, Vietnam.
Nguyen Thanh PhuongDepartment of Animal Health, Regional Animal Health Office No. 6, Ho Chi Minh City, Vietnam.
Patrick MiletoAustralian Centre for Disease Preparedness, Commonwealth Scientific and Industrial Research Organisation, Geelong, Australia.ORCID https://orcid.org/0000-0002-8249-722X
Orlando MercadoNational Animal Health and Food Testing Laboratory, National Animal and Quarantine Inspection Authority, Port Moresby, Papua New Guinea.
Felisiano da ConceiçãoNational Directorate of Veterinary Services of the Ministry of Agriculture and Fisheries, Government of Timor-Leste, Comoro, East Timor.
Joanita Bendita da Costa JongNational Directorate of Veterinary Services of the Ministry of Agriculture and Fisheries, Government of Timor-Leste, Comoro, East Timor.
Ilagi PuanaNational Animal Health and Food Testing Laboratory, National Animal and Quarantine Inspection Authority, Port Moresby, Papua New Guinea.
Matthew J NeaveAustralian Centre for Disease Preparedness, Commonwealth Scientific and Industrial Research Organisation, Geelong, Australia.ORCID https://orcid.org/0000-0002-8108-0553
David T WilliamsAustralian Centre for Disease Preparedness, Commonwealth Scientific and Industrial Research Organisation, Geelong, Australia.ORCID https://orcid.org/0000-0002-7169-149X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African swine fever virus (ASFV) is a highly stable DNA virus showing little genetic variation among genomes. This genetic stability has often posed challenges in tracking variants and identifying potential transmission chains as ASFV spreads into new regions. While mutations within individual sequenced genes are infrequent, the application of whole-genome sequencing enables the identification of neutral and functional mutations across the entire genome, contributing to a deeper understanding of ASFV evolution and epidemiology. In this study, we sequenced whole genomes from 25 ASFV positive samples collected from Vietnam, Timor-Leste and Papua New Guinea (PNG). We classified mutations across ASFV genes and non-coding regions, while identifying mutations that may act as candidates for geographic-based population genetic structuring. Overall, ASFV samples showed >99.8% genetic similarity to the Georgia 2007 isolate reference genome. Nonetheless, emergent genetic clusters rooted in geographic location were apparent. Multiple nonsynonymous mutations were found in sequenced genomes, often unique to ASFV collected within only one studied country. Of the observed mutations, four were found within genes of known function (

Indexed as

African Swine FeverAfrican Swine Fever VirusAnimalsGenetic VariationGenome, ViralGenotypeMutationPapua New GuineaPhylogenySwineVietnamAfrican swine feverASFV Genotype IIgenetic epidemiologymicroevolutionwhole-genome sequencing

Identifiers

PMID40585857
PMCPMC12204745

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.