ArticleBrain communications2025
Peak width of skeletonized mean diffusivity mediates the relationship between cerebral small vessel disease burden and cognitive impairment in community-dwelling older adults.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Global ethnic disparities in cerebral small vessel disease imaging markers and vascular risk factors: a systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peak width of skeletonized mean diffusivity (PSMD) is a reliable marker of white matter (WM) integrity in cerebral small vessel disease (CSVD). However, the mediating role of WM damage (as measured by PSMD) in the association between CSVD and cognitive impairment remains unclear. This research applied multivariate regression analysis to explore correlations among CSVD markers, PSMD and cognitive function in older community residents. Additionally, we analysed associations between PSMD and cognitive performance across different CSVD burden levels. Simple and chain mediation analyses were employed to evaluate PSMD's mediating role in the relationship among cerebrovascular risk factors, CSVD and cognitive decline. The cohort consisted of 273 participants categorized by CSVD severity into mild, moderate and severe groups. Each CSVD marker, along with PSMD, was significantly correlated with cognitive performance when controlling for demographic factors (age, sex and education) and apolipoprotein E (APOE) genotype. PSMD fully mediated the relationship between enlarged perivascular spaces and both the Mini-Mental State Examination and Modified Common Objects Sorting Test scores, while it partially mediated the relationships involving the CSVD burden, white matter hyperintensity volume, lacunes and cerebral microbleeds (indirect effect
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