Evidence map›Paper›PMID 40585815›Full record

ArticleBrain communications2025

The temporal dynamics and clinical relevance of choroid plexus measures in multiple sclerosis.

Ermelinda De Meo, Sarmad Al-Araji, Baris Kanber, Alessia Bianchi, Charmaine Hiu-Ying Yam, Ronja Christensen, Suraya Mohamud, Jed Wingrove, Omar Abdel-Mannan, Anuriti Aojula and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ermelinda De MeoQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.ORCID https://orcid.org/0000-0001-5531-1111
Sarmad Al-ArajiQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Baris KanberNational Institute for Health and Care Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, London, WC1E 6BT, UK.ORCID https://orcid.org/0000-0003-2443-8800
Alessia BianchiQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Charmaine Hiu-Ying YamQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.ORCID https://orcid.org/0000-0002-4146-2047
Ronja ChristensenQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Suraya MohamudQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Jed WingroveQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.ORCID https://orcid.org/0000-0002-0454-1299
Omar Abdel-MannanQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Anuriti AojulaQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Dimitrios ChampsasQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Weaam HamedQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Ahmed HammamNeuroradiology Department, King's College Hospital NHS Foundation, London, SE5 9RS, UK.
Dominic WilkinsNeurology Department, NHS, Redditch, WC1N 3BG, UK.
Anna HeQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Yael HacohenQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.ORCID https://orcid.org/0000-0001-8490-9657
Ferran PradosCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, WC1V 6LJ, UK.ORCID https://orcid.org/0000-0002-7872-0142
Frederik BarkhofQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Declan ChardQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.
Olga CiccarelliQueen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London, WC1B 5EH, UK.ORCID https://orcid.org/0000-0001-7485-1367

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Choroid plexus enlargement is a promising biomarker of disease activity in multiple sclerosis. However, longitudinal changes in choroid plexus volume and microstructural integrity remain unclear. This study investigated temporal changes in choroid plexus measures and their correlations with clinical disability and brain volume changes over 18 months and the entire disease duration. We recruited consecutive relapsing-remitting multiple sclerosis patients at treatment initiation who were then invited to come back for clinical, neuropsychological and brain MRI assessments at 6 and 18 months. Choroid plexus volume was measured using FreeSurfer and Gaussian Mixture Models on 3D-T1-weighted scans, and choroid plexus T1/T2 ratio was calculated from conventional 3D-T1- and T2-weighted images. Brain lesion, whole brain, grey matter, and white matter volumes were measured. Alternating conditional expectation algorithm was used to estimate trajectories of changes in choroid plexus measures over the entire disease course. Multiple linear regression and mixed effects models were used to investigate associations of choroid plexus measures with clinical and MRI measures. False discovery rate correction was applied. 422 RRMS patients were recruited [mean age: 40.8 years (SD 10.9), mean disease duration: 9.5 years (SD 17.4), median expanded disability status scale: 2.0 (IQR: 1.5-3.5); mean symbol digit modalities test score: 50.6 (SD 14.7), mean brief visuospatial memory test-revised score: 25 (SD7.6)]; 276 participants were studied at 6-months follow-up and 80 at 18-months. During the entire disease course, an initial increase in normalized choroid plexus volume was observed, followed by a plateau; T1/T2 ratio decreased initially, but then increased once the volume had stabilized. When examining changes in choroid plexus volumes over a median follow-up of 8.6 months, significant increases in both choroid plexus volumes [β = 0.45, standard error = 0.11, False discovery rate-corrected

Indexed as

choroid plexuscognitionMRImultiple sclerosispathogenesis

Identifiers

PMID40585815
PMCPMC12203544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.