ArticleBrain communications2025
Multidimensional MRI reveals cortical astrogliosis linked to dementia in Alzheimer's disease.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- MultidimensionalbioRxiv : the preprint server for biology · 2026Article
- Review
- Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brain.Research square · 2026Article
- Informed Dictionary-Guided Monte Carlo Inversion for Robust and Reproducible Multidimensional MRI.Magnetic resonance in medicine · 2026Article
- Separable multidimensional MRI signatures of cellular and structural pathology in Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- HIF-1 Targeting Intervention Renders Protection From Alzheimer's-Like Pathology in a Humanized Mice Model of HIV Infection.Journal of extracellular vesicles · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
Despite the presence of significant Alzheimer's disease pathology, characterized by amyloid β (Aβ) plaques and phosphorylated tau (pTau) tangles, some cognitively unimpaired elderly individuals do not inevitably develop dementia. Cortical astroglial inflammation, a ubiquitous feature of symptomatic Alzheimer's disease, shows a strong correlation with cognitive impairment severity, highlighting the influence of factors beyond classical pathology. However, non-invasively imaging neuroinflammation, particularly astrogliosis, using MRI remains a significant challenge. Here we sought to address this challenge and to leverage multidimensional (MD) MRI, a powerful approach that combines relaxation with diffusion MR contrasts, to map cortical astrogliosis in the human brain by accessing sub-voxel information. Our goal was to investigate whether MD-MRI can map astroglial pathology in the cerebral cortex, and if so, whether it can distinguish cognitively normal state from dementia in the presence of hallmark Alzheimer's disease neuropathological changes. We adopted a multimodal approach by integrating histological and MRI analyses using human postmortem brain samples from two independent discovery and replication cohorts.
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Registered trials
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