ArticleACS central science2025
Late-Stage Heteroarene Alkylation via Minisci Reaction with Gaseous Alkanes Enabled by Hydrogen Atom Transfer in Flow.
Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Reactivity of Nitroarenes toward Alkyl Radicals Enables Direct C-H Alkylation.Journal of the American Chemical Society · 2026Article
- Direct δ-Lactone Synthesis From Free Alcohols via Photoinduced δ-C(spAngewandte Chemie (International ed. in English) · 2026Article
- Metal-free Minisci C-H alkylation of hydrazones using aldehydes: an unexpected route to hydrazone-containing pyrimidine derivatives.RSC advances · 2026Article
- Accessing Molecular Complexity from Methane and Other Gaseous Alkanes via Photocatalytic Cascade Cyclization.Angewandte Chemie (International ed. in English) · 2026Article
- Homogeneous catalysis in continuous flow integrating photocatalysis, electrocatalysis, and automation technologies.Communications chemistry · 2025Review
- Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology.Journal of the American Chemical Society · 2025Review
- Light-Powered Late-Stage Alkylation of N‑Heteroaromatics in Flow.ACS central science · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The late-stage functionalization of complex molecules is a pivotal strategy in drug discovery, enabling the rapid optimization of lead compounds. However, the use of gaseous alkanes as alkylating agents in these processes remains underexplored due to their inertness and handling challenges. Here we present a photocatalytic platform that facilitates the alkylation of heteroarenes using abundant gaseous C1-C4 hydrocarbons under continuous-flow conditions. Through hydrogen atom transfer (HAT) catalysis, we achieve the efficient alkylation of pharmaceutically relevant compounds without the need for prefunctionalized reagents. Our method is not only scalable and sustainable but also extends to the functionalization of marketed drugs and natural products.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.