Evidence map›Paper›PMID 40585794›Full record

ArticleACS central science2025

Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor.

Robert P Sparks, William Lawless, Anna Kharitonova, Rainer Metcalf, Jamie Nunziata, Grace A Binder, Sauradip Chaudhuri, Christine S R Gambino, Michelle Wilde, Linette S Harding and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Therapeutic targeting of the cGAS-STING pathway in human disease.The Journal of clinical investigation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Robert P SparksDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
William LawlessDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Anna KharitonovaDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Rainer MetcalfDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Jamie NunziataDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Grace A BinderDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Sauradip ChaudhuriBiochemistry and Molecular Biotechnology Department, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01655, United States.ORCID https://orcid.org/0000-0003-3578-5293
Christine S R GambinoDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Michelle WildeDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Linette S HardingDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Jaret J CrewsDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Mansi GopuDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Emilia DalamangasDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Sarah LawlessDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Mark EschenfelderDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Robert M GreenBiochemistry and Molecular Biotechnology Department, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01655, United States.
Elizabeth X NompleggiDivision of Gastroenterology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01655, United States.
Timothy H TranH. Lee Moffitt Cancer Center, Research Institute at the University of South Florida, Tampa, Florida 33612, United States.
Yan YangH. Lee Moffitt Cancer Center, Research Institute at the University of South Florida, Tampa, Florida 33612, United States.
Donna V TraskDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Paul R ThompsonBiochemistry and Molecular Biotechnology Department, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01655, United States.ORCID https://orcid.org/0000-0002-1621-3372
Rekha PatelResearch Service, James A. Haley Veterans Hospital, Tampa, Florida 33612, United States.
Niketa A PatelResearch Service, James A. Haley Veterans Hospital, Tampa, Florida 33612, United States.
Wesley H BrooksDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.ORCID https://orcid.org/0000-0002-5604-3769
Guy BradleyTampa Bay Research Institute, St. Petersburg, Florida 33716, United States.ORCID https://orcid.org/0000-0001-7260-3351
Mildred E Acevedo-DuncanDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Alan C MullenDivision of Gastroenterology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01655, United States.
James W LeahyDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.ORCID https://orcid.org/0000-0003-3647-4489
Kenyon G DanielDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
Wayne C GuidaDepartment of Chemistry, University of South Florida, Tampa, Florida 33620, United States.ORCID https://orcid.org/0000-0003-3353-4853

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stimulator of interferon genes (STING) is a transmembrane endoplasmic reticulum (ER) resident protein involved in innate immunity. STING activation occurs by binding of cyclic guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate (2',3'-cGAMP) to STING, which leads to downstream production of type 1 interferons (IFN-1). We generated molecular dynamics (MD) equilibrated agonist and antagonist models of human STING (hSTING) for computer-based screening and now report the discovery of clonixeril (CXL) as the most potent non-nucleotide hSTING modulator discovered to date. We demonstrate

Identifiers

PMID40585794
PMCPMC12203428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.