ArticleCureus2025
A Comparison of TIMI (Thrombolysis in Myocardial Infarction) and GRACE (Global Registry of Acute Coronary Events) Scores, Myocardial Blush Grade, and Shock Index-Based Indices for Predicting Outcomes in STEMI Patients Undergoing Reperfusion.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- HEART Score Distribution and Association with In-Hospital Management and Outcomes in COVID-19 Survivors Presenting with Acute Chest Pain.Journal of clinical medicine · 2026Article
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality globally. Proper risk stratification is critical to guide its early management and forecast outcomes. Although traditional scoring systems such as Thrombolysis in Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) are commonly employed, more recent indices such as Shock Index (SI), Modified Shock Index (MSI), and Age Shock Index (Age SI), and Myocardial Blush Grade (MBG) provide potentially more straightforward, bedside-usable means for prognostication. This study aimed to evaluate and compare the predictive validity of SI, Age SI, MSI, and MBG with validated risk scores - TIMI and GRACE - in predicting in-hospital and 30-day outcomes in STEMI patients who are undergoing reperfusion therapy. Methods This prospective observational study was conducted from September 2023 to August 2024 at R.L. Jalappa Hospital and RLJ Narayana Hrudayalaya, Kolar. A total of 150 adult STEMI patients treated with thrombolysis or primary percutaneous coronary intervention (PCI) were enrolled. Data were examined using chi-square tests and receiver operating characteristic (ROC) curves. Outcomes were assessed as in-hospital mortality, length of stay in ICU, and 30-day major adverse cardiac events (MACE). Results GRACE score evidenced higher predictive capacity for mortality and MACE over TIMI and shock-based indices. Age SI and MBG indicated encouraging correlation with outcomes, especially when employed in combination with conventional scores. Conclusions GRACE is a potent risk stratification tool for STEMI. Yet, SI-based metrics and MBG may supplement conventional scores, thereby providing fast, bedside assessment to facilitate early intervention and enhance patient outcomes in these patients.
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