ArticleCureus2025
Evaluating Ozonated Olive Oil and Chlorhexidine Gel as a Therapeutic Intervention for Periodontitis Stage II Grade A.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis on the effect of olive oil in the treatment of periodontal diseases.Frontiers in oral health · 2025Pooled it
- A Novel Digital Tray for Customized Professional Ozonized Gel Delivery in Periodontal Maintenance: A Case Report.Case reports in dentistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Periodontal therapy aims to eliminate harmful microorganisms from the gingival sulcus. Still, factors like deep pockets, tooth anatomy, and tissue-invading bacteria can reduce the effectiveness of scaling and root planing (SRP). Antimicrobial agents are often used to enhance SRP outcomes. While chlorhexidine (CHX) is commonly used, its limitations have prompted the exploration of alternatives like ozone therapy. Ozonated olive oil has shown potential therapeutic benefits. This study compares the effectiveness of CHX and ozonated olive oil as adjuncts to SRP in treating periodontitis stage II grade A. Materials and methods A longitudinal study with 20 participants was conducted. The control group received SRP with CHX, while the test group received SRP with ozonated olive oil. Clinical parameters, including probing depth, attachment loss, and sulcus bleeding index, were measured at baseline and after three months. Data were analyzed using the Student t-test. Results Both groups showed significant improvements in clinical parameters, with no significant differences. Conclusion Ozonated olive oil may enhance SRP outcomes in periodontal disease treatment and could be a valuable adjunct. Further studies are needed to confirm its long-term efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.