ArticleCureus2025
Rotavirus-Associated Myositis in a 12-Year-Old Child.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rotavirus infection is a common cause of pediatric gastroenteritis, often self-limited but occasionally associated with extraintestinal complications. This report describes a 12-year-old vaccinated girl who presented with acute gastroenteritis and an incidental elevation of serum creatine kinase (CK). Despite the absence of muscle pain or weakness during hospitalization, laboratory findings indicated skeletal muscle involvement, with elevated CK and aldolase levels, and a predominance of CK-MM isoenzyme. Myocardial involvement and rhabdomyolysis were ruled out. The patient recovered with supportive care, and CK levels normalized after discharge, although she reported mild post-discharge fatigue. Rotavirus-associated myositis is rare and likely underrecognized, particularly in young children who may not verbalize muscle symptoms. This case highlights the importance of considering myositis in patients with elevated CK during rotavirus infection, even in the absence of overt muscular symptoms.
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