ArticleCureus2025
Investigating the Relationship Between Cortisol, a Stress Marker, and Immune Function Across Age and Gender.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the relationship between cortisol, a well-known stress marker, and immune function, focusing on how cortisol levels affect immune responses across different age groups and genders. Stress can be acute or chronic, both of which influence physiological processes in the body. Cortisol plays a key role in this process, with acute stress leading to brief elevations of cortisol that can enhance immune function, while chronic stress leads to dysregulation and immune suppression. This retrospective study, conducted at a tertiary care hospital, analyzed data from patients who underwent cortisol and complete blood count (CBC) tests between April and September 2024. The data, collected from both male and female participants of various age groups, revealed significant correlations between cortisol levels and immune parameters like total leukocyte count (TLC), lymphocyte percentage, and neutrophil percentage. Notably, cortisol was positively correlated with TLC, while it showed a weak negative correlation with lymphocyte percentage, suggesting a potential reduction in immune responsiveness with elevated cortisol levels. Gender differences were also observed, with females exhibiting a stronger negative correlation between age and lymphocyte percentage, while males showed significant correlations between cortisol levels and immune markers. These findings underscore the complex interplay between stress, cortisol, and immune function, providing insights into stress-related health conditions such as infections and autoimmune disorders.
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