Evidence map›Paper›PMID 40585618›Full record

ArticleCureus2025

Proteinuria and Palmar Clues: Rediscovering the Renal Face of Syphilis.

Alexis M Chrystman, Anvit Reddy, Yasasvhinie Santharam, Oshin Rai, Shiguang Liu, Ronald L Mars, Rafik Jacob

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexis M ChrystmanInternal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Anvit ReddyInternal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Yasasvhinie SantharamInternal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Oshin RaiInternal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Shiguang LiuPathology and Laboratory Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Ronald L MarsNephrology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Rafik JacobInternal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Syphilis is a sexually transmitted infection that remains prevalent in our population despite available curative treatment. Here, we present a case of a 35-year-old female with a presenting symptom of dry rash on multiple regions of her body. This rash was not initially identified as syphilis, and the patient's disease progressed to involve the kidney. This systemic manifestation of secondary syphilis led to a membranous nephropathy (MN). Following treatment of the underlying infection, the patient's symptoms and renal dysfunction fully resolved. This case highlights the wide-ranging impacts of syphilis as it continues to spread in our population, and that early recognition and targeted therapy can lead to favorable renal outcomes with a resolution of systemic manifestations.

Indexed as

kidney biopsykidney involvement in syphilismembranous nephropathyrare presentation of nephrotic syndromesecondary syphilisskin punch biopsy

Identifiers

PMID40585618
PMCPMC12205720

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.