Evidence map›Paper›PMID 40585531›Full record

ArticleRegenerative biomaterials2025

Development of a mechanical adaptable, moisture retention capable, injectable and adhesive organohydrogel for nucleus pulposus repairing.

Yaping Wang, Dong Wang, Chu Gao, Chuxin Zhou, Xiao Lin, Di Wang, Liu Yang, Huan Zhou, Lei Yang

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yaping WangCenter for Health Science and Engineering, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300131, People's Republic of China.
Dong WangInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Peoples' Republic of China.
Chu GaoInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Peoples' Republic of China.
Chuxin ZhouInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Peoples' Republic of China.
Xiao LinOrthopedic Institute and Department of Orthopedics, The First Affiliated Hospital, Soochow University, Suzhou 215000, People's Republic of China.
Di WangInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Peoples' Republic of China.
Liu YangInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Peoples' Republic of China.
Huan ZhouCenter for Health Science and Engineering, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300131, People's Republic of China.
Lei YangCenter for Health Science and Engineering, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300131, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing mechanical adaptable injectable gel with nucleus pulposus (NP) repairing capability for minimally invasive treatment of intervertebral disc degeneration (IDD) is of great importance in medical practice. In current work, inspired by the outcomes of polyvinyl alcohol and glycerol based injectable organohydrogel (GPG) in IDD control and the great potential of animal glue in tissue adhesion, a novel injectable and self-crosslinking adhesive organohydrogel GPG-AG was fabricated. The mechanical performance of the GPG-AG was systematically studied, possessing viscoelastic properties close to NP accompanied with strong adhesion to intervertebral disc to avoid dynamic loading induced leakage postinjection. In addition, the swelling behavior, water retention capability and degradation of the organohydrogel

Indexed as

intervertebral disc degenerationmechanical adaptablenucleus pulposusorganohydrogelreactive oxygen species

Identifiers

PMID40585531
PMCPMC12202143

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.