Evidence map›Paper›PMID 40585528›Full record

ReviewTherapeutic advances in ophthalmology

Repeated corneal crosslinking for progressive keratoconus: efficiency and safety.

Eleftherios Chatzimichail, Georgios Chondrozoumakis, Farideh Doroodgar, Efstathios Vounotrypidis, Georgios D Panos, Nicolas Feltgen, Zisis Gatzioufas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Therapeutic advances in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eleftherios ChatzimichailDepartment of Ophthalmology, University Hospital of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-4283-5260
Georgios ChondrozoumakisDepartment of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece.ORCID https://orcid.org/0009-0006-1844-1949
Farideh DoroodgarTranslational Ophthalmology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Efstathios VounotrypidisDepartment of Ophthalmology, Ulm University, Ulm, Germany.ORCID https://orcid.org/0000-0002-9833-2200
Georgios D PanosDepartment of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Nicolas FeltgenDepartment of Ophthalmology, University Hospital of Basel, Basel, Switzerland.
Zisis GatzioufasDepartment of Ophthalmology, University Hospital of Basel, Mittlerestrasse 91, Basel, 4031, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal crosslinking (CXL) was first introduced in clinical practice in 2003. Since then, this procedure has been established as the first-line treatment in the management of progressive keratoconus. Over the last years, many different protocols have emerged, each one of them with variable clinical outcomes and safety profile. Progression of keratoconus after primary CXL is very rare, but it has been reported in the literature. This review summarises the existing data on repeated CXL after primary failure, emphasising on clinical efficacy and safety.

Indexed as

efficiencyprimary corneal crosslinking failureprogressive keratoconusrepeated corneal crosslinkingsafety

Identifiers

PMID40585528
PMCPMC12206266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.