ArticleiScience2025
Enhancing photodynamic therapy for cutaneous squamous cell carcinoma with ACP-U soluble microneedles.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Combination of 5-Aminolevulinic Acid and Indocyanine Green in Photodynamic Therapy for Squamous Cell Carcinoma: An In Vivo Study.International journal of molecular sciences · 2026Article
- Laser-based therapies in the management of non-melanoma skin cancers: a narrative review.Lasers in medical science · 2026Review
- Recent Advances in Novel Drug Delivery Systems for the Management of Cutaneous Squamous Cell Carcinoma.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic therapy (PDT) is recognized as a promising treatment for cutaneous squamous cell carcinoma (cSCC). The effectiveness of PDT is limited due to the skin barrier and cell membrane impeding the delivery of the photosensitizer and molecular oxygen levels at the treatment site. In this study, ulvan microneedles were loaded with poly(lactic-co-glycolic acid) (PLGA) nanoparticles, encapsulating 5-aminolevulinic acid (ALA) and catalase (CAT). The results showed that the ALA-CAT-PLGA-Ulvan (ACP-U) microneedles were successfully synthesized and were able to penetrate the skin efficiently, dissolve quickly, and subsequently release the ACP nanoparticles to the target site. With good biocompatibility both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.