ReviewFood science & nutrition2025
Optimizing Chlorogenic Acid Extraction From Spent Coffee Grounds: A Comparative Review of Conventional and Non-Conventional Techniques.
Review in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Liposomes, Niosomes, Ethosomes, and Transethosomes for Curcumin and Chlorogenic Acid Delivery: Formulation Design and Dermal Performance.Antioxidants (Basel, Switzerland) · 2026Review
- Upcycling Spent Coffee Grounds: Approaches, Emerging Concepts and Applications.Foods (Basel, Switzerland) · 2026Review
- Chlorogenic acid mitigates calcium oxalate monohydrate crystal-induced epithelial-to-mesenchymal transition in renal epithelial cells via suppression of HSP60 expression and p38 signaling.Cellular & molecular biology letters · 2026Article
- Selective Enrichment of Chlorogenic Acid and Related Phenolic Acids from Spent Coffee Grounds by Ultrasound-Assisted Extraction with Deep Eutectic Solvents.Foods (Basel, Switzerland) · 2026Article
- Optimizing Chlorogenic Acid Extraction From Spent Coffee Grounds: A Comparative Review of Conventional and Non-Conventional Techniques.Food science & nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spent coffee grounds (SCGs) pose a significant environmental burden for coffee-producing industries due to the large quantities generated during coffee brewing. However, SCGs also represent an underexplored and sustainable source of bioactive compounds, particularly chlorogenic acid (CGA), known for its antioxidant, anti-inflammatory, and antimicrobial properties. This systematic review evaluates and compares various conventional and non-conventional extraction methods for CGA from SCGs, assessing their efficacy in terms of extraction yield, environmental impact, cost-efficiency, and processing time, factors often overlooked in earlier studies. Ultrasound-assisted extraction (UAE) emerged as the most effective technique, yielding the highest quantity of CGA (587.7 ± 46.6 mg/g), using ethanol as a solvent with a solid-to-liquid ratio of 1:30. UAE was also identified as the most environmentally friendly technique. In contrast, conventional solvent extraction (CSE) provided a moderate CGA yield (39.5 ± 2.1 mg/g) using water as a solvent and was the most cost-efficient technique. Microwave-assisted extraction (MAE) offered the fastest extraction time with a CGA yield of 84 ± 2.8 mg/g. By integrating technical performance with sustainability considerations, this study offers new insights into the optimization of SCG valorization. Furthermore, it supports the advancement of circular bioeconomy strategies through the efficient recovery of high-value bioactive compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.