ArticleOxford medical case reports2025
Atypical anti-glomerular basement membrane disease: two case reports.
Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Atypical Anti-Glomerular Basement Membrane (anti-GBM) Disease, a variant of the rare autoimmune disorder Goodpasture's disease, presents unique challenges in diagnosis and management. This article presents two cases of atypical anti-GBM disease characterized by negative serological tests for anti-GBM antibodies, minimal renal impact on kidney biopsy, and absence of pulmonary involvement. These cases underscore the evolving spectrum of renal anti-GBM-related conditions and the need for a nuanced approach to diagnosis and treatment. Treatment with high-dose steroids resulted in favorable outcomes in both cases, highlighting the importance of individualized management strategies, especially given the absence of standardized recommendations for this uncommon presentation. Further research is warranted to elucidate the pathophysiology and optimal management of atypical anti-GBM disease.
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