Evidence map›Paper›PMID 40585429›Full record

ArticleSynthetic and systems biotechnology2025

Improving fidaxomicin production through ARTP mutagenesis and fermentation optimization in

Jing-Yi Ruan, Huang Xie, Yi-Lei Zheng, Qing-Wei Zhao, Xin-Ai Chen, Zhong-Yuan Lyu, Yong-Quan Li

Abstract read
In one paragraph

Article in Synthetic and systems biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Production improvement of dalbavancin precursor A40926B0 inSynthetic and systems biotechnology · 2027
    Article
  2. Screening and ARTP mutagenesis-based breeding of high-cellulase-producing strains.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing-Yi RuanFirst Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, China.
Huang XieFirst Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, China.
Yi-Lei ZhengFirst Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, China.
Qing-Wei ZhaoFirst Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, China.
Xin-Ai ChenFirst Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, China.
Zhong-Yuan LyuInstitute of Biopharmaceuticals, School of Pharmaceutical Sciences, Taizhou University, Taizhou, China.
Yong-Quan LiFirst Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fidaxomicin, a macrolide antibiotic, is widely used to treat

Indexed as

ARTP mutagenesisDual-reporter systemFermentation optimizationFidaxomicin

Identifiers

PMID40585429
PMCPMC12205737

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.