Evidence map›Paper›PMID 40585414›Full record

ArticleADMET & DMPK2025

Effect of surfactants and polymer composition on the characteristics of polyhydroxyalkanoate nanoparticles.

Aleksei Dorokhin, Sergei Lipaikin, Galina Ryltseva, Alexander Shabanov, Kristina Sapozhnikova, Tatiana Volova, Sergei Kachin, Ekaterina Shishatskaya

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In one paragraph

Article in ADMET & DMPK, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aleksei DorokhinSiberian Federal University, 79 Svobodny pr., Krasnoyarsk 660041, Russia.
Sergei LipaikinSiberian Federal University, 79 Svobodny pr., Krasnoyarsk 660041, Russia.
Galina RyltsevaSiberian Federal University, 79 Svobodny pr., Krasnoyarsk 660041, Russia.
Alexander ShabanovL.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, 50/12 Akademgorodok, Krasnoyarsk 660036, Russia.
Kristina SapozhnikovaSiberian Federal University, 79 Svobodny pr., Krasnoyarsk 660041, Russia.
Tatiana VolovaSiberian Federal University, 79 Svobodny pr., Krasnoyarsk 660041, Russia.
Sergei KachinSiberian Federal University, 79 Svobodny pr., Krasnoyarsk 660041, Russia.
Ekaterina ShishatskayaSiberian Federal University, 79 Svobodny pr., Krasnoyarsk 660041, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Polyhydroxyalkanoates (PHAs) are biodegradable polyesters of bacterial origin that are actively studied as matrices for the preparation of nanoparticulate drug delivery systems. The most significant parameters affecting PHAs nanoparticles (NPs) characteristics are polymer composition and the type of surfactant used to stabilize the emulsion during NPs preparation. However, there are only a few studies in the literature investigating the effect of these factors on the characteristics of PHA NPs. Experimental approach: Blank poly(3-hydroxybutyrate) (P3HB) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (P3HBV) NPs were produced and characterized in terms of their size, morphology and zeta potential. Poly(vinyl alcohol) (PVA) with various molecular weights (31-50 and 85-124 kDa), as well as Tween 20 (TW20), Tween 80 (TW80), sodium deoxycholate (SDC) and sodium dodecyl sulphate (SDS) were used as surfactants. For NPs that formed stable aqueous suspensions and had the most desirable characteristics (P3HB/PVA Key results: NPs of both P3HB and P3HBV obtained using PVA with the Conclusion: In this study, the effect of various non-ionic and anionic surfactants on the characteristics of P3HB and P3HBV NPs was investigated. PVA

Indexed as

P3HBP3HBVpolyvinyl alcoholsodium deoxycholatesodium dodecyl sulphateTween 80

Identifiers

PMID40585414
PMCPMC12205925

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.