Evidence map›Paper›PMID 40585389›Full record

ArticleBioactive materials2025

ROS-balancing-engineered bio-heterojunction hydrogel accelerated the infected bone regeneration based on Sono-chemo dynamic therapy.

Jiani Xu, Fanshangming Zhou, Lingyan Cao, Huilin Wang, Jiani Hu, Shuo Qiu, Yulan Liu, Yan Zhang, Jie Wang, Xinquan Jiang

Abstract read
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Nanoparticle-integrated smart hydrogel with HJournal of nanobiotechnology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Ultrasound- and NIR-Responsive Polydextran/Black TiOACS applied materials & interfaces · 2025
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiani XuDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China.
Fanshangming ZhouShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China.
Lingyan CaoDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China.
Huilin WangCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, 200011, PR China.
Jiani HuCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, 200011, PR China.
Shuo QiuCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, 200011, PR China.
Yulan LiuDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China.
Yan ZhangSchool of Materials Science and Engineering, Shanghai University of Engineering Science, Shanghai, 201620, PR China.
Jie WangDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China.
Xinquan JiangShanghai Stomatological Hospital Fudan University, Shanghai, 201100, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxic deep-seated infections in refractory environments impede wound healing and exacerbate antibiotic resistance. Sonodynamic therapy (SDT) shows promise in combating pathogenic bacteria; however, the excessive reactive oxygen species (ROS) generated during the process often induce severe inflammatory responses, hindering tissue regeneration. To overcome these limitations, we have developed a multifunctional hydrogel, inspired by the dynamic regulatory mechanisms of rhizobia. GSH-SF/PeMA/MXene-TiO

Indexed as

Bio-heterojunctionHypoxic deep infectionsReactive oxygen speciesSonodynamic therapyTissue regeneration

Identifiers

PMID40585389
PMCPMC12206024

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.