Evidence map›Paper›PMID 40585385›Full record

ReviewBioactive materials2025

Revolutionizing neural regeneration with smart responsive materials: Current insights and future prospects.

Hongxia Gao, Huoyun Shen, Xunrui Zhang, Yaqiong Liu, Yuqing Shang, Shaolan Sun, Wenchao Guan, Xiaosong Gu, Yumin Yang, Guicai Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongxia GaoKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Huoyun ShenKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Xunrui ZhangDepartment of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, 226000, China.
Yaqiong LiuKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Yuqing ShangKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Shaolan SunKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Wenchao GuanKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Xiaosong GuKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Yumin YangKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Guicai LiKey Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smart-responsive materials, which possess the capacity to receive signals from the environment and engage in dynamic communication with it, have significantly expanded the frontiers of tissue engineering and regenerative medicine. They hold substantial potential for the evolution of precise and distinctive therapeutic systems within the domain of neural regeneration. In the wake of the continuous advancement of science and technology, researchers have delved deeply into diverse response mechanisms and have successively developed multiple generations of smart responsive materials (SRM) for applications such as drug delivery, graft fabrication, and detection platforms in neural regeneration, yet a lack of a comprehensive and systematic review to provide informative references for researchers in the related fields. Therefore, in this review, we comprehensively summarize the response mechanisms and classifications of smart-responsive materials, with particular emphasis on the research and development progress and application modalities of various SRM in the field of neural regeneration, including peripheral nerve injury, spinal cord injury, and trauma brain injury. Additionally, the limitations of diverse smart-responsive materials in neural regeneration are meticulously dissected, and the efforts for developing new smart-responsive materials for neural regeneration was emphasized. Eventually, the prospects and forthcoming trends of smart-responsive materials in nerve regeneration are prominently spotlighted. It is anticipated that this review will furnish a crucial reference for the utilization of smart-responsive materials across various tissue engineering fields.

Indexed as

Nerve graftsNerve regenerationSmart materialsStimulus responseTissue engineering

Identifiers

PMID40585385
PMCPMC12206011

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.