Evidence map›Paper›PMID 40585371›Full record

ArticleiScience2025

The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s.

Xianzhi Gao, Xin Shen, Qianying Xu, Yan Zeng, Linjia Dong, Shenghui Hong, Huihui Jin, Qianqian Wang, Di Wang, Linrong Lu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xianzhi GaoLiang Zhu Laboratory, Zhejiang University Medical Center, Hangzhou, China.
Xin ShenCo-facility centre, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China.
Qianying XuZhejiang University School of Medicine, Hangzhou, China.
Yan ZengZhejiang University School of Medicine, Hangzhou, China.
Linjia DongSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Shenghui HongLaboratory Animal Center, Zhejiang University, Hangzhou, China.
Huihui JinLaboratory Animal Center, Zhejiang University, Hangzhou, China.
Qianqian WangLaboratory Animal Center, Zhejiang University, Hangzhou, China.
Di WangZhejiang University School of Medicine, Hangzhou, China.
Linrong LuZhejiang University School of Medicine, Hangzhou, China.
Lie WangLiang Zhu Laboratory, Zhejiang University Medical Center, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group 3 innate lymphoid cells (ILC3s) serve as critical guardians of mucosal immunity. However, the transcriptional networks governing their function remain incompletely characterized. Here, we demonstrate that interferon regulatory factor 4 (IRF4) is essential for maintaining intestinal ILC3 homeostasis and function. IRF4-deficient mice exhibit reduced NKp46

Indexed as

Biological sciencesHealth sciencesMolecular biologyMolecular biology experimental approach

Identifiers

PMID40585371
PMCPMC12205599

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.