Evidence map›Paper›PMID 40585366›Full record

ArticleiScience2025

Volume electron microscopy reveals 3D synaptic nanoarchitecture in postmortem human prefrontal cortex.

Jill R Glausier, Matthew Maier, Cedric Bouchet-Marquis, Ken Wu, Tabitha Banks-Tibbs, Darlene Melchitzky, Jiying Ning, David A Lewis, Zachary Freyberg

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jill R GlausierDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Matthew MaierDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Cedric Bouchet-MarquisMaterials and Structural Analysis, Thermo Fisher Scientific, Hillsboro, OR, USA.
Ken WuMaterials and Structural Analysis, Thermo Fisher Scientific, Hillsboro, OR, USA.
Tabitha Banks-TibbsDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Darlene MelchitzkyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Jiying NingDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
David A LewisDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Zachary FreybergDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Novel roles of VGLUT in sex differences in dopamine neuron vulnerability to environmental toxicant-induced neurodegenerationR01ES034037 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZACHARY FREYBERG · 2023 to 2026
$2.3M
Basis of Glutamatergic Synaptic Dysfunction in SchizophreniaR01MH132544 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JILL RENEE' Glausier · 2024 to 2026
$1.7M
Novel roles for the circadian transcription factor NPAS2 and striatal dopamine D3 receptor signaling in diurnal fentanyl craving and relapseR01DA061243 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ZACHARY FREYBERG, Ryan W Logan · 2024 to 2026
$1.4M
Request for a ThermoFisher Helios 5UC DualBeamS10MH133575 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY, GLAUSIER, JILL RENEE' · 2023 to 2023
$600k
A novel role for midbrain glutamate co-transmitting neurons in alcohol drinking and motivated behaviorsR21AA028800 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY, LOGAN, RYAN W · 2021 to 2022
$446k
NIAAA NIH HHS R21 AA028800NIDA NIH HHS R01 DA061243NIEHS NIH HHS R01 ES034037NIMH NIH HHS R01 MH132544NIMH NIH HHS S10 MH133575
6 · The paper itself

Abstract

Synaptic function is reflected in quantifiable ultrastructural features using electron microscopy (EM) approaches. This coupling of synaptic function and ultrastructure suggests that

Indexed as

Neuroscience

Identifiers

PMID40585366
PMCPMC12205628

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.