Accessing carbon, boron and germanium spiro stereocentres in a unified catalytic enantioselective approach.

Yi-Xuan Cao, Anne-Sophie Chauvin, Shuo Tong, Layth Alama, Nicolai Cramer

Abstract read

In one paragraph

Article in Nature catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Construction of remote dual stereocenters by electrochemical cobalt-catalyzed enantioselective desymmetrization.Nature communications · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi-Xuan CaoLaboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnic Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0002-0634-7369

Anne-Sophie ChauvinGroup of Coordination Chemistry, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0001-9222-3866

Shuo TongMOE Key Laboratory of Bioorganic Phosphorus and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China.ORCID 0000-0002-7982-2546

Layth AlamaLaboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnic Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0009-0008-9357-6784

Nicolai CramerLaboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnic Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0001-5740-8494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Achieving substrate generality in asymmetric catalysis remains a long-standing goal, particularly for the selective construction of chiral heteroatoms. Compared with carbon, sulfur, phosphorus and silicon stereogenic centres, methods for the construction of their boron and germanium congeners remain very scarce. Chiral (hetero) spirocycles are of relevance in several research domains. Methods effective for constructing carbon-centred chiral spirocycles do not translate to boron and germanium, leaving these chiral centres unexplored. We describe a unified strategy for constructing carbon, boron and germanium-centred chiral spirocyclic skeletons via enantioselective hetero [2+2+2] cycloaddition of a bis-alkyne with a nitrile. A chiral designer Ni(0)

Indexed as

Asymmetric catalysisOptical materialsSynthetic chemistry methodology

Identifiers

PMID40585298

DOI10.1038/s41929-025-01352-3

PMCPMC12198011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.