Evidence map›Paper›PMID 40585280›Full record

ArticleNAR cancer2025

Discovery of epigenetically silenced tumour suppressor genes in aggressive breast cancer through a computational approach.

Anne-Laure Vitte, Florent Chuffart, Emmanuelle Jacquet, Eleni Nika, Mireille Mousseau, Ina Jung, Séverine Tabone-Eglinger, Thomas Bachelot, Sophie Rousseaux, Saadi Khochbin and 1 more

Abstract read
In one paragraph

Article in NAR cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Multidimensional roles and clinical significance of GATA3 in breast cancer.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anne-Laure VitteUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, 38000 Grenoble, France.ORCID 0000-0002-8091-7673
Florent ChuffartUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, 38000 Grenoble, France.ORCID 0000-0001-6064-5183
Emmanuelle JacquetUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, 38000 Grenoble, France.ORCID 0000-0001-5445-9720
Eleni NikaDepartment of Pathology, CHU Grenoble Alpes, CS 10217 - 38043 Grenoble cedex 09, France.
Mireille MousseauMedical Oncology Unit, Cancer and Blood Diseases Department, CHU Grenoble Alpes, CS 10217 - 38043 Grenoble cedex 09, France.
Ina JungUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, 38000 Grenoble, France.ORCID 0009-0003-1579-4982
Séverine Tabone-EglingerPlateforme de Gestion des Echantillons Biologiques, Centre Léon Bérard, Cancer Research Center of Lyon, Université de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Lyon, France.ORCID 0000-0003-4247-1321
Thomas BachelotDepartment of Oncology, Centre Léon Bérard, Cancer Research Center of Lyon, Université de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Lyon, France.ORCID 0000-0002-0866-9484
Sophie RousseauxUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, 38000 Grenoble, France.ORCID 0000-0001-5246-5350
Saadi KhochbinUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, 38000 Grenoble, France.ORCID 0000-0002-0455-0857
Ekaterina Bourova-FlinUniversité Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institute for Advanced Biosciences, 38000 Grenoble, France.ORCID 0000-0002-5673-9045

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is characterized by genetic and epigenetic deregulations, leading to aberrant expression of tissue-specific genes that are normally silent in healthy breast tissue. Our previous work identified the embryonic stem cell-specific gene

Indexed as

Breast NeoplasmsDNA (Cytosine-5-)-MethyltransferasesEpigenesis, GeneticGATA3 Transcription FactorGene SilencingGenes, Tumor SuppressorComputational BiologyDNA MethylationDNA Methyltransferase 3BFemaleGene Expression Regulation, NeoplasticHumansPromoter Regions, GeneticDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BGATA3 protein, humanGATA3 Transcription Factor

Identifiers

PMID40585280
PMCPMC12203794

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.