Evidence map›Paper›PMID 40585275›Full record

ArticleJournal of molecular and cellular cardiology plus2025

Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling.

Nikole J Byrne, Christoph Koentges, Elisabeth Khan, Katharina Pfeil, Robert Sandulescu, Sayan Bakshi, Carolin Költgen, Ivan Vosko, Johannes Gollmer, Thomas Rathner and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Nikole J ByrneDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Christoph KoentgesInstitute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Elisabeth KhanDepartment of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Germany.
Katharina PfeilDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Robert SandulescuDivision of Cardiology I, Heart Center Freiburg University, University of Freiburg, Freiburg, Germany.
Sayan BakshiDivision of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Carolin KöltgenDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Ivan VoskoDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Johannes GollmerDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Thomas RathnerDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Günter RothBioCopy GmbH, Emmendingen, Germany.
Michael M HoffmannInstitute for Clinical Chemistry and Laboratory Medicine, University of Freiburg, Freiburg, Germany.
Katja E OdeningTranslational Cardiology, Department of Cardiology, Inselspital, Bern University Hospital, and Department of Physiology, University of Bern, Bern, Switzerland.
Hauke HorstmannDivision of Cardiology I, Heart Center Freiburg University, University of Freiburg, Freiburg, Germany.
Luke A PotterDivision of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Christoph BodeDivision of Cardiology I, Heart Center Freiburg University, University of Freiburg, Freiburg, Germany.
Dennis WolfDivision of Cardiology I, Heart Center Freiburg University, University of Freiburg, Freiburg, Germany.
Harald SourijDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Senka Ljubojevic-HolzerDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Markus WallnerDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Peter P RainerDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Simon SedejDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Daniel ScherrDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Dirk von LewinskiDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Adam R WendeDivision of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Andreas ZirlikDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.
Heiko BuggerDepartment of Cardiology, University Heart Center Graz, Medical University of Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Sirtuin 4 (SIRT4) is a mitochondrially-localized stress-responsive NAD Methods and results: Mice with cardiomyocyte-specific overexpression of Conclusions:

Indexed as

FibrosisHeart failureOxidative stressReactive oxygen speciesSIRT4Sirtuin

Identifiers

PMID40585275
PMCPMC12206323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.