Evidence map›Paper›PMID 40585254›Full record

ArticleResearch square2025

Dasatinib and quercetin senolytic treatment delays early onset intervertebral disc degeneration in SM/J mice.

Makarand Risbud, Emanuel Novais, Olivia Ottone, Esther Akande, Ruteja Barve

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Makarand RisbudThomas Jefferson University.
Emanuel NovaisThomas Jefferson University.
Olivia OttoneThomas Jefferson University.
Esther AkandeThomas Jefferson University.
Ruteja BarveWashington University.ORCID 0000-0002-1171-9761

Funding

Role of HIF-1 in Intervertebral Disc FunctionR01AR055655 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V · 2008 to 2023
$6.1M
Disruption of Osmoregulation Promotes Degenerative Disc DiseaseR01AR064733 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V, SHAPIRO, IRVING M · 2014 to 2018
$2.4M
Pathogenesis of Inflammation-driven Intervertebral Disc Herniation: The Role of Syndecan 4R01AR074813 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V · 2019 to 2023
$2.3M
NIAMS NIH HHS R01 AR055655NIAMS NIH HHS R01 AR064733NIAMS NIH HHS R01 AR074813
6 · The paper itself

Abstract

Genetic background is a major determinant of disc degeneration, a leading cause of chronic back pain and disability. Herein, we demonstrate that premature disc cell senescence contributes to early-onset degeneration in SM/J mice and test two systemic senotherapeutic strategies to mitigate it: Navitoclax (Nav.) and a cocktail of Dasatinib and Quercetin (DQ). While Nav. treatment did not improve severe degeneration in SM/J mice, DQ-treated mice showed lower grades of degeneration and decreased abundance of senescence markers p19

Indexed as

dasatinibdegenerationintervertebral discquercetinSASPsenescencesenolyticsSM/J micetranscriptome

Identifiers

PMID40585254
PMCPMC12204365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.