ArticleResearch square2025
Multimodal Prediction of Psychosis in the Prospective MoBa Birth Cohort.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
16 authors.
Funding
Abstract
There is a need for improved early psychosis detection beyond the traditional clinical high-risk strategy. Using the Norwegian Mother, Father and Child cohort study, we examined the predictive ability of self-reported psychotic experiences (Community Assessment of Psychic Experiences; CAPE) at age 14, in addition to general mental health factors, parent and childhood psychiatric diagnoses, schizophrenia polygenic risk scores, and birth-related factors, to predict subsequent psychosis onset using three machine learning approaches for imbalanced data. We explored also a multimodal prediction framework. For unimodal classification, we observed best balanced accuracies with general mental health factors (67.27 ± 1.76%), and CAPE (65.95 ± 1.09%). Multimodal models improved classification accuracy (68.38 ± 2.16%). With validation and additional model refinement, these features may be useful for initial screening within clinical stepped assessment frameworks.
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