RAB4A DRIVES PROINFLAMMATORY CD4

Joy S Park, Daniel Krakko, Jessica Nolan, Brandon Wyman, Mahsa Sadeghzadeh, Andras Perl

Abstract readPreprint

In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joy S ParkDepartments of Medicine, State University of New York, Upstate Medical University, Norton College of Medicine, Syracuse, New York 13210.ORCID https://orcid.org/0000-0001-8211-9950

Daniel KrakkoDepartments of Medicine, State University of New York, Upstate Medical University, Norton College of Medicine, Syracuse, New York 13210.ORCID https://orcid.org/0000-0003-1552-7377

Jessica NolanDepartments of Medicine, State University of New York, Upstate Medical University, Norton College of Medicine, Syracuse, New York 13210.

Brandon WymanDepartments of Medicine, State University of New York, Upstate Medical University, Norton College of Medicine, Syracuse, New York 13210.ORCID https://orcid.org/0000-0002-5660-4693

Mahsa SadeghzadehDepartments of Medicine, State University of New York, Upstate Medical University, Norton College of Medicine, Syracuse, New York 13210.

Andras PerlDepartments of Medicine, State University of New York, Upstate Medical University, Norton College of Medicine, Syracuse, New York 13210.ORCID https://orcid.org/0000-0002-5017-1348

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rab4A, a small GTPase overexpressed in T cells of patients with systemic lupus erythematosus (SLE), has been shown to activate mechanistic target of rapamycin (mTOR) signaling, which promotes proinflammatory T cell development and predisposes to nephritis in SLE. In this study, we demonstrate that Rab4A facilitates the endocytic recycling and surface expression of CD38, which, in turn, triggers NAD

Indexed as

autoimmunityCD38CD4+ T cellsendosome trafficIL-2metabolismmTORNAD+Rab4Asystemic lupus erythematosus

Identifiers

PMID40585226

DOI10.21203/rs.3.rs-6787101/v1

PMCPMC12204502

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.