Evidence map›Paper›PMID 40585201›Full record

ArticleResearch square2025

Feature-specific threat coding in lateral septum guides defensive action.

Dionnet Leandro Bhatti Mazo, Amanda Loren Pasqualini, Sherry Jingjing Wu, Marc Z C Berger, Christopher M Reid, Salvador Ignacio Brito, Shenfeng Qiu, Pat Levitt, Todd Erryl Anthony, Gord Fishell

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Dionnet Leandro Bhatti MazoDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Amanda Loren PasqualiniF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0196-4827
Sherry Jingjing WuDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9625-1661
Marc Z C BergerDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Christopher M ReidWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Salvador Ignacio BritoProgram in Neuroscience, Harvard Medical School, Boston, MA, USA.
Shenfeng QiuDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ, USA.ORCID 0000-0002-0730-1602
Pat LevittChildren's Hospital Los Angeles, The Saban Research Institute, Los Angeles, CA, USA.
Todd Erryl AnthonyF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Gord FishellDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9640-9278

Funding

Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Gabriel Kreiman · 1998 to 2026
$21.3M
The molecular and cellular basis of cortical interneuron divergenceR37MH071679 · NIMH · HARVARD MEDICAL SCHOOL · PI GORDON J FISHELL · 2022 to 2026
$4.1M
UC Irvine Center for the production and distribution of cell-type-specific viral targeting reagentsU24MH133236 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI FISHELL, GORDON J, XU, XIANGMIN · 2023 to 2025
$3.6M
Genetic dissection of lateral septal circuitry that controls stress-induced persistent anxiety states-Diversity SupplementR01MH117421 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI SCHWARZ, THOMAS L. · 2019 to 2023
$2.9M
MET receptor tyrosine kinase and the development of forebrain circuitsR01MH111619 · NIMH · UNIVERSITY OF ARIZONA · PI QIU, SHENFENG · 2017 to 2021
$1.9M
Functional and molecular organization of lateral septum in threat processingR36MH136796 · NIMH · HARVARD MEDICAL SCHOOL · PI BHATTI MAZO, DIONNET LEANDRO · 2024 to 2025
$91k
NEI NIH HHS P30 EY012196NIMH NIH HHS R01 MH111619NIMH NIH HHS R01 MH117421NIMH NIH HHS R36 MH136796NIMH NIH HHS R37 MH071679NIMH NIH HHS U24 MH133236
6 · The paper itself

Abstract

The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information, with internal state and prior experience. The lateral septum (LS), an inhibitory structure in the limbic forebrain, is thought to integrate these higher-order 'cognitive' signals to regulate defensive responses

Identifiers

PMID40585201
PMCPMC12204492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.