ArticlemedRxiv : the preprint server for health sciences2025
Evaluating the accuracy of
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
31 authors.
Funding
Abstract
Existing methods to identify patients infected with Salmonella enterica Typhi (S. Typhi) or Paratyphi are inadequately accurate, affordable, and efficient. We evaluated the discriminatory power of antibodies to S. Typhi hemolysin E (HlyE) and lipopolysaccharide (LPS) in Bangladesh, Nepal, and Pakistan. Plasma concentrations of anti-HlyE and LPS IgA were measured in blood culture-confirmed enteric fever cases and in febrile controls with laboratory-confirmed alternative etiology. Receiver operating characteristic analyses showed that combining anti-LPS and HlyE IgA distinguished enteric fever cases from other febrile illnesses with an area under the curve (AUC) of 0.93. Anti-LPS IgA alone performed nearly as well (AUC 0.92). In children under 5, the combination outperformed individual biomarkers (AUC 0.96 vs. 0.94 (HlyE), 0.93 (LPS)) and was most accurate in Bangladesh and Pakistan compared to Nepal. These findings support anti-HlyE and LPS IgA ELISA as an accurate method to identify enteric fever in endemic settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.