Evidence map›Paper›PMID 40585156›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Unanticipated Global Emergence of Multiple

Liang Ma, Ming Hao, Weizhong Chang, Xilong Deng, Junfeng Sun, Marwan M Azar, Alexia Cusini, Thomas Fehr, Sara Gianella, Norihiko Goto and 19 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Liang MaCritical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Ming HaoLaboratory of Human Retrovirology and lmmunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Weizhong ChangLaboratory of Human Retrovirology and lmmunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Xilong DengCritical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Junfeng SunCritical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Marwan M AzarDepartment of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, and U.S. Medical Affairs, GlaxoSmithKline Pharmaceuticals, New Haven, Connecticut, USA.
Alexia CusiniDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Thomas FehrDepartment of Internal Medicine, Cantonal Hospital Graubuenden, Chur, and University of Zurich, Zurich, Switzerland.
Sara GianellaInfectious Diseases and Global Public Health, University of California San Diego, La Jolla, California, USA.
Norihiko GotoTransplant Nephrology, Goto Clinic, Nagoya, Japan.
Jannik Helweg-LarsenDepartment of Infectious Diseases, Rigshospitalet-Copenhagen University Hospital, Copenhagen, Denmark.
Grace HandleyCritical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Cedric HirzelDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Laurence HuangDivision of HIV, Infectious Diseases and Global Medicine, and Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California, USA.
Regina KonradBavarian Health and Food Safety Authority (Bavarian LGL), Oberschleissheim, Germany.
Nicolas J MuellerUniversity Hospital of Zurich Transplant Center, Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Shinichi OkaJapan Institute for Health Security, Tokyo, Japan.
Lingai PanDepartment of Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Li PengDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Andreas A RostvedDepartment of Infectious Diseases, Rigshospitalet-Copenhagen University Hospital, Copenhagen, Denmark.
Monica SassiCritical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Andreas SingBavarian Health and Food Safety Authority (Bavarian LGL), Oberschleissheim, Germany.
Benjamin SpielmanCritical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Laura F WalshCritical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Yubao WangRespiratory Department, Tianjin Medical University General Hospital, Tianjin, China.
Hirohisa YazakiShizuku-Naika Clinic Higashi-Ikebukuro, Tokyo, Japan.
Lizbeth HedstromDepartment of Biology and Department of Chemistry, Brandeis University, Waltham, Massachusetts, USA.
Tomozumi ImamichiLaboratory of Human Retrovirology and lmmunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Joseph A KovacsCritical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.

Funding

Inflammation, Aging, Microbes, Obstructive Lung Disease and Diffusion Abnormalities (I AM OLD-DA) Study - Diversity SupplementR01HL128156 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE, HUNT, PETER W · 2015 to 2024
$7.1M
Integrated Analysis of Microbial and Genomic data in Obstructive Lung Disease (I AM GOLD) StudyR01HL143998 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTENSON, STEPHANIE A, HUANG, LAURENCE · 2019 to 2022
$3.2M
NHLBI NIH HHS R01 HL128156NHLBI NIH HHS R01 HL143998
6 · The paper itself

Abstract

Background: Classified by the WHO as one of the 19 most dangerous fungal pathogens, Methods: In this international multicenter retrospective observational study, Results: Six Conclusions: This study suggests that the widespread use of MPA in SOT recipients has unexpectedly driven the emergence of multiple

Indexed as

CellCeptinosine monophosphate dehydrogenasemutationsmycophenolate mofetilmycophenolic acidoutbreaksPneumocystis jiroveciisolid organ transplantation

Identifiers

PMID40585156
PMCPMC12204247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.