Evidence map›Paper›PMID 40585132›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Ancestry Calibration of Polygenic Risk Scores Improves Risk Stratification and Effect Estimation in African American Adults.

Luciana B Vargas, Mariah C Meyer, Iain R Konigsberg, Aastha Kakar, Patrick M Carry, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium, Yun Li, Alana C Jones, Hemant K Tiwari, Vinodh Srinivasasainagendra and 10 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Luciana B VargasDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-9074-2010
Mariah C MeyerDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-9635-5196
Iain R KonigsbergDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-7356-100X
Aastha KakarDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0009-0001-5192-1286
Patrick M CarryDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-2989-7080
Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium
Yun LiDepartment of Biostatistics and Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-9275-4189
Alana C JonesMedical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-3827-2426
Hemant K TiwariDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0003-4016-1856
Vinodh SrinivasasainagendraDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Nicole D ArmstrongMedical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-6483-4560
Eimear E KennyInstitute for Genomic Health and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9198-759X
Bogdan PasaniucDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0227-2056
Marguerite R IrvinMedical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1442-2023
Michael H ChoChanning Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-4907-1657
Maggie A StanislawskiDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-7768-8868
Sridharan RaghavanDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0003-0643-4873
Jonathan A ShorttDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-7980-5420
Leslie A LangeDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-4220-6766
Ethan M LangeDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-7075-4287

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Polygenic Risk Score Methods Development Consortium Coordinating CenterU01HG011697 · NHGRI · UNIVERSITY OF WASHINGTON · PI Kenneth M. Rice · 2021 to 2026
$8.8M
Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7M
PRS Center for Admixed Populations (CAPE)U01HG011715 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI Eimear Elizabeth Kenny, Leslie A Lange · 2021 to 2026
$5.2M
Integrative genomic, transcriptomic and proteomic studies of pulmonary function and COPDR01HL153248 · NHLBI · UNIVERSITY OF VIRGINIA · PI CHO, MICHAEL H., MANICHAIKUL, ANI WANG · 2021 to 2024
$2.8M
GEneration and assessment of Multi-omic informed Subtypes of Type 2 Diabetes in Diverse Populations (GEMS-T2D)U01DK140757 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Josep Maria Mercader, KRISTINA Marie UTZSCHNEIDER · 2024 to 2026
$2.3M
Identifying Subtypes of COPD Using Metabolomic and Genomic ApproachesR01HL168199 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO · 2024 to 2026
$2.1M
NHGRI NIH HHS U01 HG011697NHGRI NIH HHS U01 HG011715NHLBI NIH HHS R01 HL135142NHLBI NIH HHS R01 HL153248NHLBI NIH HHS R01 HL168199NIDDK NIH HHS L30 DK106874NIDDK NIH HHS U01 DK140757NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Polygenic risk score (PRS) distributions vary across populations, complicating PRS risk assessment. We evaluated the impact of

Indexed as

admixtureancestry calibrationgenetic similarityheightpolygenic risk scores (PRS)risk predictiontype 2 diabetes

Identifiers

PMID40585132
PMCPMC12204301

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.