Evidence map›Paper›PMID 40585126›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Hotspots of human mutation point to clonal expansions in spermatogonia.

Vladimir Seplyarskiy, Mikhail A Moldovan, Evan Koch, Prathitha Kar, Matthew Dc Neville, Raheleh Rahbari, Shamil Sunyaev

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Vladimir SeplyarskiyDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3161-8770
Mikhail A MoldovanDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8876-6494
Evan KochDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1124-4559
Prathitha KarDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4091-6860
Matthew Dc NevilleCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0001-5816-7936
Raheleh RahbariCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, United Kingdom.ORCID 0000-0002-1839-7785
Shamil SunyaevDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5715-5677

Funding

Statistical methods for studies of rare variantsR01MH101244 · NIMH · HARVARD MEDICAL SCHOOL · PI Benjamin Michael Neale, ALKES L PRICE · 2013 to 2026
$9.4M
Predicting the impact of genetic variants, genes and pathways on human DiseaseU01HG012009 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALKES L PRICE, Soumya Raychaudhuri · 2021 to 2026
$4.2M
NHGRI NIH HHS U01 HG012009NIMH NIH HHS R01 MH101244
6 · The paper itself

Abstract

In renewing tissues, mutations conferring selective advantage may result in clonal expansions

Identifiers

PMID40585126
PMCPMC12204251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.