Evidence map›Paper›PMID 40585112›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Facets of language performance in early-onset and late-onset Alzheimer's disease dementia.

Jeanne Gallée, Laura E Gibbons, Seo-Eun Choi, Michael Lee, Phoebe Scollard, Emily H Trittschuh, Jesse Mez, Andrew J Saykin, Nancy S Foldi, Shubhabrata Mukherjee and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jeanne GalléeCenter for Psychometric Analyses of Aging and Neurodegeneration, Department of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-9338-2727
Laura E GibbonsCenter for Psychometric Analyses of Aging and Neurodegeneration, Department of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-5054-2543
Seo-Eun ChoiCenter for Psychometric Analyses of Aging and Neurodegeneration, Department of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-2163-688X
Michael LeeCenter for Psychometric Analyses of Aging and Neurodegeneration, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Phoebe ScollardCenter for Psychometric Analyses of Aging and Neurodegeneration, Department of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-4094-938X
Emily H TrittschuhDepartment of Psychiatry and Behavior Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0003-0557-1542
Jesse MezDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0003-1438-5442
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-1376-8532
Nancy S FoldiDepartment of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, New York, 10065 USA.ORCID 0000-0001-8810-8558
Shubhabrata MukherjeeCenter for Psychometric Analyses of Aging and Neurodegeneration, Department of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-2522-2884
Paul K CraneCenter for Psychometric Analyses of Aging and Neurodegeneration, Department of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-4278-7465

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI SUMAN JAYADEV · 2020 to 2026
$29.0M
Genetic Architecture of Pure Alzheimer's Disease and Mixed PathologyR01AG082730 · NIA · UNIVERSITY OF WASHINGTON · PI David William Fardo, Shubhabrata Mukherjee · 2023 to 2026
$4.0M
NIA NIH HHS P30 AG066509NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG082730NIA NIH HHS U24 AG074855
6 · The paper itself

Abstract

backgroundEarly-onset Alzheimer's disease dementia (EOAD) is characterized by more pronounced cognitive decline than late-onset AD dementia (LOAD). Characteristic performance in spoken language remains undefined.

methodA cross-sectional analysis of 1,189 people with EOAD and 4,646 with LOAD from the National Alzheimer's Coordinating Center (NACC).

resultBased on data from their first NACC visit with AD, there was considerable heterogeneity in language performance across people with EOAD and LOAD. The distribution of naming ability was similar across these groups. On average, people with LOAD had better performance than people with EOAD for category fluency, letter fluency, and spoken lexical retrieval, and had lower Clinical Dementia Rating (CDR DISCUSSION: At diagnosis, EOAD and LOAD language profiles are distinct. There is substantial variability in both groups in multiple aspects of language.

Indexed as

Alzheimer’s disease dementiaearly-onsetlanguagelate-onsetnon-amnestic

Identifiers

PMID40585112
PMCPMC12204297

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.