Evidence map›Paper›PMID 40585108›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury.

Lacey W Heinsberg, Aboli Kesbhat, Bailey Petersen, Lauren Kaseman, Zachary Stec, Nivinthiga Anton, Patrick M Kochanek, Keith Owen Yeates, Daniel E Weeks, Yvette P Conley and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Lacey W HeinsbergDepartment of Health Promotion and Development, School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-7690-5485
Aboli KesbhatDepartment of Physical Medicine & Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bailey PetersenDepartment of Physical Medicine & Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-8521-9324
Lauren KasemanDepartment of Physical Medicine & Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Zachary StecDepartment of Physical Medicine & Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-4358-3598
Nivinthiga AntonDepartment of Physical Medicine & Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Patrick M KochanekDepartment of Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2627-913X
Keith Owen YeatesDepartment of Psychology, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-7680-2892
Daniel E WeeksDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9410-7228
Yvette P ConleyDepartment of Health Promotion and Development, School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1784-6067
Amery Treble-BarnaDepartment of Physical Medicine & Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-3980-7293

Funding

Methylomics of pediatric traumatic brain injury and neurobehavioral recoveryR01NS135492 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Amery Treble-Barna · 2024 to 2026
$1.8M
Epigenetic Influences on Neurobehavioral Recovery following Pediatric Traumatic Brain InjuryK01HD097030 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBLE-BARNA, AMERY · 2019 to 2023
$642k
NICHD NIH HHS K01 HD097030NINDS NIH HHS R01 NS135492
6 · The paper itself

Abstract

Pediatric traumatic brain injury (TBI) triggers biological changes that may differ from those observed in non-brain injuries.

Indexed as

BDNFbiomarkersepigeneticsprecision medicine

Identifiers

PMID40585108
PMCPMC12204258

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.