Evidence map›Paper›PMID 40585105›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Diverse Genomes, Shared Health: Insights from a Health System Biobank.

Roni Haas, Michael P Margolis, Angela Wei, Takafumi N Yamaguchi, Jeffrey Feng, Thai Tran, Veronica Tozzo, Katelyn J Queen, Mohammed Faizal Eeman Mootor, Vishakha Patil and 25 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Roni HaasDepartment of Human Genetics, University of California, Los Angeles, USA.ORCID 0000-0003-1505-2965
Michael P MargolisDepartment of Human Genetics, University of California, Los Angeles, USA.
Angela WeiDepartment of Human Genetics, University of California, Los Angeles, USA.
Takafumi N YamaguchiDepartment of Human Genetics, University of California, Los Angeles, USA.
Jeffrey FengDepartment of Radiological Sciences, University of California, Los Angeles, USA.
Thai TranDepartment of Neurology, University of California, Los Angeles, USA.
Veronica TozzoDepartment of Computational Medicine, University of California, Los Angeles, USA.ORCID 0000-0001-8538-9198
Katelyn J QueenDepartment of Medicine, University of California, Los Angeles, USA.
Mohammed Faizal Eeman MootorDepartment of Human Genetics, University of California, Los Angeles, USA.
Vishakha PatilDepartment of Neurology, University of California, Los Angeles, USA.
Michael E BroudyUCLA Health Information Technology, Office of Health Informatics and Analytics.
Paul TungUCLA Health Information Technology, Office of Health Informatics and Analytics.
Shafiul AlamUCLA Health Information Technology, Office of Health Informatics and Analytics.
Danielle B MartinezUCLA Health Information Technology, Office of Health Informatics and Analytics.
Yash PatelDepartment of Human Genetics, University of California, Los Angeles, USA.
Nicole ZeltserDepartment of Human Genetics, University of California, Los Angeles, USA.
Rupert Hugh-WhiteDepartment of Human Genetics, University of California, Los Angeles, USA.
Jaron ArbetDepartment of Human Genetics, University of California, Los Angeles, USA.
Christa CaggianoInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, New York.
Ruhollah ShemiraniInstitute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, New York.
Mao TianDepartment of Human Genetics, University of California, Los Angeles, USA.
Prapti ThapaliyaUCLA Health Information Technology, Office of Health Informatics and Analytics.
Lora EloyanUCLA Health Information Technology, Office of Health Informatics and Analytics.
Lawrence O ChenDepartment of Human Genetics, University of California, Los Angeles, USA.
Maryam AriannejadInstitute for Precision Health, University of California, Los Angeles, USA.
Clara LajonchereInstitute for Precision Health, University of California, Los Angeles, USA.
UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working Group, UCLA Health IT HPC Team, Regeneron Genetics Center
Bogdan PasaniucDepartment of Genetics Perelman School of Medicine University of Pennsylvania.
Alex BuiJonsson Comprehensive Cancer Center, University of California, Los Angeles, USA.
Valerie A ArboledaDepartment of Human Genetics, University of California, Los Angeles, USA.
Timothy S ChangDepartment of Neurology, University of California, Los Angeles, USA.ORCID 0000-0002-9225-9874
Noah ZaitlenDepartment of Human Genetics, University of California, Los Angeles, USA.
Paul T SpellmanDepartment of Medicine, University of California, Los Angeles, USA.ORCID 0000-0002-4810-0022
Paul C BoutrosDepartment of Human Genetics, University of California, Los Angeles, USA.ORCID 0000-0003-0553-7520
Daniel H GeschwindDepartment of Human Genetics, University of California, Los Angeles, USA.

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Uncovering the Genetic Mechanisms of the Chromosome 17q21.31 Tau Haplotype on Neurodegeneration Risk in FTD and PSPU54NS123746 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H, GOATE, ALISON M · 2021 to 2025
$9.4M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
Genomic Approaches to Population Health in Multi-Ethnic Hospital SystemsR01HG011345 · NHGRI · UNIVERSITY OF COLORADO DENVER · PI ARBOLEDA, VALERIE A, GIGNOUX, CHRISTOPHER R · 2020 to 2023
$3.1M
Medical Imaging Informatics Training GrantT32EB016640 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALEX BUI, William Hsu · 2013 to 2026
$2.3M
Identifying Undiagnosed Alzheimer’s Disease in Understudied PopulationsR01AG085518 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Timothy S Chang · 2024 to 2026
$2.3M
Rare Genetic Risk and Gene Networks in TauopathyK08AG065519 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHANG, TIMOTHY S · 2020 to 2024
$887k
Mapping cell type specific isoform diversity in the human brain: dissecting mechanisms of alternative splicing in ASDF30MH135712 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Michael Margolis · 2024 to 2026
$138k
Identifying sources of variable penetrance and expressivity in monogenic diseases at population scaleF31HG013462 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEI, ANGELA N · 2024 to 2025
$86k
Predicting prostate cancer clinical outcomes with germline genomic biomarkersF31CA281168 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZELTSER, NICOLE · 2024 to 2025
$83k
NCI NIH HHS F31 CA281168NHGRI NIH HHS F31 HG013462NHGRI NIH HHS R01 HG011345NHGRI NIH HHS T32 HG002536NIA NIH HHS K08 AG065519NIA NIH HHS R01 AG085518NIBIB NIH HHS T32 EB016640NIGMS NIH HHS T32 GM008042NIMH NIH HHS F30 MH135712NINDS NIH HHS U54 NS123746
6 · The paper itself

Abstract

Coupling genetic profiling with electronic health records from hospital biobanks is a foundational resource for precision medicine. However, lack of ancestral heterogeneity limits discovery and generalizability. We leveraged the UCLA ATLAS Community Health Initiative, a diverse biobank with >35% non-European participants in a single health system, to inform disease prevalence and genetic risk across five continental and 36 fine-scale ancestry groups. Analyzing clinical and genetic data for 93,937 individuals, 61,797 with whole-exome sequencing (WES), we identified novel associations between genetic variants and phenotypes, including

Identifiers

PMID40585105
PMCPMC12204455

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.