Evidence map›Paper›PMID 40585104›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Ranked placement of phage predation as a determinant of dehydration severity among cholera patients in Bangladesh.

N Madi, Md Abu Sayeed, E T Cato, A Creasy-Marrazzo, K Islam, Md I Ul Khabir, Md T R Bhuiyan, Y Begum, E Freeman, A Vustepalli and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

N MadiDepartment of Microbiology & Immunology, McGill University, Montréal, Canada.
Md Abu SayeedDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
E T CatoDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
A Creasy-MarrazzoDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
K IslamInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Md I Ul KhabirInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Md T R BhuiyanInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.ORCID 0000-0003-3755-4763
Y BegumInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
E FreemanDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
A VustepalliDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
L BrinkleyDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.
M KamatDepartment of Chemistry, University of Florida, Gainesville, FL, USA.
L S BaileyDepartment of Chemistry, University of Florida, Gainesville, FL, USA.
K B BassoDepartment of Chemistry, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-1268-6655
F QadriInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.ORCID 0000-0002-8928-9888
A I KhanInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.ORCID 0000-0003-3751-1974
B J ShapiroDepartment of Microbiology & Immunology, McGill University, Montréal, Canada.ORCID 0000-0001-6819-8699
E J NelsonDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, FL, USA.

Funding

Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
The evaluation of a mHealth platform for diarrheal disease decision support and real-time epidemiologyR21TW010182 · FIC · UNIVERSITY OF FLORIDA · PI KHAN, ASHRAFUL ISLAM, NELSON, ERIC JORGE · 2016 to 2017
$320k
FIC NIH HHS R21 TW010182NIH HHS S10 OD021758
6 · The paper itself

Abstract

Phage predation is inversely associated with severe cholera yet its importance as a determinant of dehydration severity is unknown relative to other factors. Here we used machine learning to assess and rank potential host, microbial, and environmental factors as determinants of severe dehydration among a cohort of cholera patients enrolled at hospital admission across Bangladesh. We found the phage to pathogen ratio ranked among the top classifying features, placing just behind patient age and admission location. We advocate that phage predation is a key factor to include in the characterization of cholera for scientific, clinical and epidemiological applications.

Indexed as

AMRantibioticsantimicrobial resistancebacteriophageCholeradehydrationdiarrheadiarrhoeamachine learningmass spectrometrymetagenomicsphageVibrio cholerae

Identifiers

PMID40585104
PMCPMC12204250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.