ArticlemedRxiv : the preprint server for health sciences2025
CLINICAL DIAGNOSIS CODES IDENTIFY PATIENTS UNLIKELY TO RECEIVE ORDERS FOR FECAL IMMUNOCHEMICAL TESTS.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Organized screening programs automate fecal immunochemical test (FIT) outreach based on chronological age. However, providers and patients may defer screening due to coexisting conditions, which can be captured by International Classification of Disease, 10 Methods: We included screen-eligible patients with a primary care visit between June 2022 and June 2023. We enumerated and compared the frequency of each ICD-10 code between patients with and without a FIT ordered. We conducted a subgroup analysis including only those with a Charlson comorbidity index (CCI) <5. Results: We identified 15,020 screen-eligible patients, with 10,187 (67.8%) patients having had a FIT order and 4,833 (32.3%) patients without a FIT order. Of the 1,215 ICD-10 codes examined, 96 were significantly associated with not having a FIT order. One broad category of codes pertained to digestive diseases such as benign and malignant colonic neoplasms (ICD-10 code C18, odds ratio (OR) 0.06, 95% CI [0.001-0.44]) and diverticular disease (K57, OR 0.26 [0.18-0.36]). Another category was comorbid conditions which included frailty (R54, OR 0.14 [0.03-0.55]) and paralysis (G82, OR 0.14 [0.03-0.55]). Those with acute conditions such as cervical fractures (S12, OR 0.23 [0.10-0.48]) and cryptococcosis (B45, OR 0.05 [0.001-0.38]) were also less likely to have a FIT order. Among the patients with CCI<5, 41 codes were significantly associated with not having a FIT order, including heart failure (I50, OR 0.55 [0.43-0.71]) and chronic kidney disease (N18, OR 0.58 [0.43-0.77]). Conclusion: Patients deferred from screening were more likely to have ICD-10 codes signifying digestive diseases, comorbidities, and acute conditions. Even among patients with fewer co-morbid conditions, we identified health conditions that were associated with screening deferral. Future work should consider whether screening programs could incorporate ICD-10 codes to align FIT outreach more closely with provider and patient preferences.
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