Evidence map›Paper›PMID 40585093›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions.

Olivier Parent, Zaki Alasmar, Sophia Osborne, Aurélie Bussy, Manuela Costantino, Jérémie P Fouquet, Daniela Quesada, Alexandre Pastor-Bernier, Alfonso Fajardo-Valdez, Alexa Pichet-Binette and 9 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Olivier ParentCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.ORCID 0000-0002-3177-0353
Zaki AlasmarCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.ORCID 0009-0002-1164-6950
Sophia OsborneCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.
Aurélie BussyCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.ORCID 0000-0001-6695-9941
Manuela CostantinoCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.
Jérémie P FouquetCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.ORCID 0000-0001-6815-7037
Daniela QuesadaIntegrated Program in Neuroscience, McGill University, Montreal, Canada.
Alexandre Pastor-BernierCenter for the Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health University Institute, Montreal, Canada.ORCID 0000-0002-8865-6551
Alfonso Fajardo-ValdezCenter for the Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health University Institute, Montreal, Canada.
Alexa Pichet-BinetteDépartement de pharmacologie et physiologie, Université de Montréal, Montreal, Canada.ORCID 0000-0001-5218-3337
Ann McQuarrieDepartment of Anatomy and Cell Biology, McGill University, Montreal, Canada.
Josefina MaranzanoDépartement d'Anatomie, Université du Québec à Trois-Rivières, Trois-Rivières, Canada.
Gabriel A DevenyiCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.ORCID 0000-0002-7766-1187
Christopher J SteeleDepartment of Psychology, Concordia University, Montreal, Canada.ORCID 0000-0003-1656-7928
Sylvia VilleneuveCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.ORCID 0000-0003-2338-0467
PREVENT-AD Research Group
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Mahsa DadarCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.ORCID 0000-0003-4008-2672
M Mallar ChakravartyCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada.ORCID 0000-0002-0759-5508

Funding

Investigating the impact of loneliness on brain aging and pre-symptomatic Alzheimer's disease progressionR01AG068563 · NIA · MCGILL UNIVERSITY · PI BZDOK, DANILO, SPRENG, ROBERT NATHAN · 2020 to 2024
$2.3M
NIA NIH HHS R01 AG068563
6 · The paper itself

Abstract

White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative etiology. Current imaging methods have lacked the specificity to disentangle biological processes underlying WMHs

Indexed as

Alzheimer’s diseasemicrostructural MRIsmall vessel diseaseWhite matter hyperintensities

Identifiers

PMID40585093
PMCPMC12204449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.