Evidence map›Paper›PMID 40585043›Full record

ArticleJournal of inflammation research2025

Cytokine Signatures as Biomarkers of Clinical Remission in Rheumatoid Arthritis.

Wei Su, Yang Xiao, Xiaohong Chen, Yan Wu, Bitao Wu, Qiang Yang, Bi Peng, Jie Tang, Yuwei Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei Su *Department of Medicine Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Yang Xiao *Department of Medicine Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Xiaohong Chen *Department of Medicine Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.ORCID 0000-0002-0967-4525
Yan WuDepartment of Medicine Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Bitao WuDepartment of Medicine Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Qiang YangDepartment of Medicine Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Bi PengDepartment of Medicine Laboratory, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan, People's Republic of China.
Jie TangDepartment of Blood Transfusion, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.
Yuwei YangDepartment of Medicine Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Variations in cytokine levels have been observed in patients with rheumatoid arthritis (RA), which contribute to immune dysfunction. This study aimed to investigate the potential of intricate cytokine networks for predicting the clinical remission of RA. Methods: In total, 164 patients with RA and 69 healthy individuals were included in this study. We investigated the levels of interleukins (ILs, including IL1β, IL2, IL4, IL5, IL6, IL8, IL10, IL12P70, and IL17), interferons (IFNs, including IFNα and IFNγ), tumor necrosis factor-alpha (TNFα), and immunoinflammatory markers, and subsequently analyzed their association and diagnostic potential in RA remission. Results: In all patients with RA, the prevalence of the release of more than six or seven cytokines was 25.0% or 18.9%, respectively, and presented nearly or the highest consistency with the prevalence of non-remission RA ( Conclusion: Our study suggests that IL6, TNFα, and IL12P70 may plot a cytokine release pattern for non-remission of RA, and are associated with its initiation, progression, and manifestation.

Indexed as

clinical remissioncytokine releasepatternpredictionrheumatoid arthritis

Identifiers

PMID40585043
PMCPMC12206424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.