Evidence map›Paper›PMID 40585034›Full record

ArticleMaterials today. Bio2025

Dextran-functionalized cerium oxide nanoparticles for treating diabetic wound infections by synergy between antibacterial activity and immune modulation.

Xiaojie Yan, Wenfu Zheng, Yiming Yu, Rufang Liu, Youhuan Gong, Mengting Huang, Mingde Fan, Le Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaojie YanAcademician Workstation, Cancer Research Center, The Jiangxi Province Key Laboratory for Diagnosis, Treatment, and Rehabilitation of Cancer in Chinese Medicine, Jiangxi University of Chinese Medicine, No. 1688 Meiling Avenue, Xinjian District, Nanchang, 330004, Jiangxi, PR China.
Wenfu ZhengCAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Haidian District, Beijing, 100190, PR China.
Yiming YuAcademician Workstation, Cancer Research Center, The Jiangxi Province Key Laboratory for Diagnosis, Treatment, and Rehabilitation of Cancer in Chinese Medicine, Jiangxi University of Chinese Medicine, No. 1688 Meiling Avenue, Xinjian District, Nanchang, 330004, Jiangxi, PR China.
Rufang LiuAcademician Workstation, Cancer Research Center, The Jiangxi Province Key Laboratory for Diagnosis, Treatment, and Rehabilitation of Cancer in Chinese Medicine, Jiangxi University of Chinese Medicine, No. 1688 Meiling Avenue, Xinjian District, Nanchang, 330004, Jiangxi, PR China.
Youhuan GongAcademician Workstation, Cancer Research Center, The Jiangxi Province Key Laboratory for Diagnosis, Treatment, and Rehabilitation of Cancer in Chinese Medicine, Jiangxi University of Chinese Medicine, No. 1688 Meiling Avenue, Xinjian District, Nanchang, 330004, Jiangxi, PR China.
Mengting HuangAcademician Workstation, Cancer Research Center, The Jiangxi Province Key Laboratory for Diagnosis, Treatment, and Rehabilitation of Cancer in Chinese Medicine, Jiangxi University of Chinese Medicine, No. 1688 Meiling Avenue, Xinjian District, Nanchang, 330004, Jiangxi, PR China.
Mingde FanDepartment of Neurosurgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Street, Jinan, 250033, Shandong, PR China.
Le WangAcademician Workstation, Cancer Research Center, The Jiangxi Province Key Laboratory for Diagnosis, Treatment, and Rehabilitation of Cancer in Chinese Medicine, Jiangxi University of Chinese Medicine, No. 1688 Meiling Avenue, Xinjian District, Nanchang, 330004, Jiangxi, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wounds, characterized by recurrent infections, drug resistance, and immunosuppression, pose a formidable clinical challenge which can hardly be adequately managed by conventional antibiotics. Herein, we present dextran-functionalized cerium oxide nanoparticles (Dex-CeNPs) to cure bacterial infected diabetic wounds. The Dex-CeNPs not only had excellent antibacterial activity, but also promoted the shift of macrophages from the proinflammatory M1 phenotype to the proregenerative M2 phenotype. By synergizing the antibacterial activity and immune modulating activity, the Dex-CeNPs promoted the healing of methicillin-resistant

Indexed as

Antibacterial effectCerium oxide nanoparticlesDiabetic woundImmune activationMRSA infection

Identifiers

PMID40585034
PMCPMC12205673

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.